The Department of Health and Human Services and National Institutes of Health has announced this Funding Opportunity Announcement (FOA) to
support a Brazil-US Regional Prospective Observational Research in Tuberculosis
(RePORT) network to leverage the robust clinical research infrastructure of
Brazil to advance the current understanding of the community, host and
microbial factors that impact outcomes of tuberculosis (TB) infection and TB
disease, especially among persons with HIV (PWH), including drug-resistant TB,
to facilitate development of tools to improve treatment outcomes at the
individual level and to inform strategies to curtail the TB epidemic at the
public health level.
Objectives
The primary objective of this initiative is to
enable a network of Brazilian and U.S. scientists to advance current
understanding of the community, host and microbial factors that impact outcomes
of TB infection and TB disease, especially among PWH, including drug-resistant
TB (DR-TB), to facilitate development of tools to improve treatment outcomes at
the individual level and to inform strategies to curtail the TB epidemic at the
public health level.
This bilateral initiative between the United
States and Brazil will support a Brazil-US Regional Prospective Observational
Research in Tuberculosis (RePORT) network that will leverage the strong
clinical research infrastructure within Brazil to facilitate a robust research
plan. Research proposed should address TB/HIV priorities of relevance to NIAID
and the Brazilian National Plan to End Tuberculosis as a Public Health Problem
(Plano Nacional Pelo Fim da Tuberculose como Problema de Saúde Pública) by
providing evidence-based strategies towards ending the TB and HIV epidemics.
The research outcomes from the projects conducted through the network are also
expected to inform Brazil’s national TB control strategy.
The following TB and TB/HIV research areas will
be supported:
- Characterization of the risk
factors for and molecular epidemiology of DR-TB in Brazil.
- Elucidation of strategies to
impact the transmission, incidence, and prevalence of TB in Brazil,
including implementation research, or factors that may inform such strategies.
- Development and/or validation
of new diagnostics and biomarkers that predict progression to active TB
and treatment outcomes of active TB.
- Mechanisms and markers of
protection from progression of infection to disease.
- Impact and interactive pathogenesis
of TB comorbidities, such as HIV or diabetes.
Research projects that include the following are
encouraged:
- Molecular epidemiology of DR-TB
in Brazil.
- Development of new diagnostic
tests for prognostic biomarkers and/or active and latent TB in conjunction
with laboratories and clinical centers in Brazil.
- Research aiming to understand
the two-way pathogenesis, impact on clinical outcomes, and associated
biomarkers of TB and comorbidities, such as HIV and diabetes.
- Discovery/confirmation of host
and microbial factors and mechanisms that affect the risk, dynamics,
pathophysiology, and transmission of latent and active TB in children and
adults.
- Research towards the continued
development of TB vaccines.
- Observational and
implementation studies that bridge the knowledge-practice gap in TB
diagnosis, treatment, and prevention.
Funding Information
- Funds Available and Anticipated
Number of Awards: NIAID intends to commit $1.0 million in FY 2022 to fund
1 award.
- Award Budget: Recommended
budget for direct costs of up to $700,000 may be requested.
- Award Project Period: The scope
of the proposed project should determine the project period. The maximum
project period is 5 years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled
Institutions of Higher Education
- Private Institutions of Higher
Education
- The following types of Higher
Education Institutions are always encouraged to apply for NIH support as
Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges
and Universities (HBCUs)
- Tribally Controlled Colleges
and Universities (TCCUs)
- Alaska Native and Native
Hawaiian Serving Institutions
- Asian American Native
American Pacific Islander Serving Institutions (AANAPISIs)
- Nonprofits Other Than
Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS
Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3)
IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations
(Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal
Governments (Federally Recognized)
- Indian/Native American Tribal
Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the
Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing
Authorities/Indian Housing Authorities
- Native American Tribal
Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based
Organizations
- Regional Organizations
- Non-domestic (non-U.S.)
Entities (Foreign Institutions)
Post Date - 06-Aug-2021